Department of Natural Product Biosynthesis
Max Planck Institute for Chemical Ecology
Hans-Knöll-Straße 8, 07745 Jena, Germany
oconnor (at) ice.mpg.de
Publications
Publication List
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Single-cell multi-omics enabled discovery of alkaloid biosynthetic pathway genes in the medical plant Catharanthus roseus.
Li, C., Wood, J.C., Vu, A.H., Hamilton, J.P., Lopez, C.E.R., Payne, R.M.E., Serna Guerrero, D.A., Yamamoto, K., Vaillancourt, B., Caputi, L.*, O’Connor, S.E.*, Buell, C.R.*
Bioarchive
doi: https://doi.org/10.1101/2022.07.04.498697
Kamileen, M.O., DeMars, M.D. 2nd, Hong, B., Nakamura, Y., Paetz, C., Lichman, B.R., Sonawane, P.D., Caputi, L.*, O'Connor, S.E.* (2022)
J. Am. Chem. Soc. 144, 19673-19679.
Expansion of the catalytic repertoire of alcohol dehydrogenases in plant metabolism.
Langley, C., Tatsis, E., Hong, B., Nakamura, Y., Paetz, C., Stevenson, C.E.M., Basquin, J., Lawson, D.M., Caputi, L.*, O’Connor, S.E.* (2022) Angew. Chem. Intl. Ed. 61, e202210934
Reconstitution of monoterpene indole alkaloid biosynthesis in Nicotiana benthamiana.
Dudley, Q.M., Jo, S., Serna Guerrero, D.A., O’Connor, S.E., Caputi, L.*, Patron, N.J.* (2022)
Communications Biology, 5, 949.
Biosynthesis of iridoid sex pheromones in aphids.
Koellner, T.G.*, David, A., Luck, K., Kunert, G., Beran, F., Zhou, J.-J., Caputi, L., O’Connor, S.E.* (2022) Proc. Natl. Acad. Sci. 119, e2211254119.
A biocatalytic toolkit for the control of iridoid stereochemistry.
Hernández Lozada, N.J., Hong, B., Wood, J.C., Caputi, L. Basquin, J., Chuang, L., Kunert, M., Rodríguez López, C.E., Langley, C., Zhao, D., Buell, C.R., Lichman, B.R., O'Connor, S.E.* (2022) Nature Commun. 13, 4718.
Hong, B., Grzech, D., Caputi, L., Sonawane, P., López, C.E.R., Kamileen, M.O., Hernández Lozada, N.J., Grabe, V., O'Connor, S.E.* (2022) Nature. 207, 617-622.
Boccia, M., Grzech, D., Lopes, A.A., O'Connor, S.E.*, Caputi, L.* (2022) Front. Plant Sci. 13, 919443.
A microbial supply chain for production of the anti-cancer drug vinblastine.
Zhang, J., Hansen, L.G., Gudich, O., Viehrig, K., Lassen, L.M.M., Schrübbers, L., Adhikari, K.B., Rubaszka, P, Carrasquer-Alvarez, E., Chen, L., D'Ambrosio, V., Lehka, B., Haidar, A.K., Nallapareddy, S., Giannakou, K., Laloux, M., Arsovska, D., Jørgensen, M.A.K., Chan, L.J.G., Kristensen, M., Christensen, H.B., Sudarsan, S., Stander, E.A., Baidoo, E., Petzold, C.J., Wulff, T., O'Connor, S.E., Courdavault, V., Jensen, M.K.*, Keasling, J.D.* (2022) Nature. 609, 341-347.
Imaging MS Analysis in Catharanthus roseus.
Yamamoto, K., Takahashi, K., O'Connor, S.E., Mimura, T.* (2022) Methods Mol. Biol. 2505, 33-43.
More than a Catharanthus plant: A multicellular and pluri-organelle alkaloid-producing factory.
Kulagina, N., Méteignier, L.V., Papon, N., O'Connor, S.E., Courdavault, V.* (2022) Curr. Opin. Plant Biol. 2022, 67, 102200.
Rodríguez-López, C.E.*, Jiang, Y., Kamileen, M.O., Lichman, B.R., Hong, B., Vaillancourt, B., Buell, C.R., O'Connor, S.E.* (2022) Mol. Biol. Evol. 39, msac057.
Koudounas, K., Guirimand, G., Rojas Hoyos, L.F., Carqueijeiro, I., Lemos Cruz, P., Stander, E., Kulagina, N., Perrin, J, Oudin, A., Besseau, S., Lanoue, A., Atehortùa, L., St-Pierre, B., Giglioli-Guivarc'h, N., Papon, N., O'Connor, S.E., Courdavault, V. (2022) Plant Cell Physiol. 63, 200-216.
Genome assembly of the medicinal plant Voacanga thouarsii.
Cuello, C., Stander, E.A., Jansen, H.J., Dugé de Bernonville, T., Lanoue, A., Giglioli-Guivarc'h, N., Papon, N., Dirks, R.P., Jensen, M.K., O'Connor, S.E., Besseau, S., Courdavault, V.* (2022) Genome Biol. Evol. 14, evac158.
In vivo characterization of key iridoid biosynthesis pathway genes in catnip (Nepeta cataria).
Palmer, L., Chuang, L., Siegmund, M., Kunert, M., Yamamoto, K., Sonawane, P.D., O’Connor, S.E.* (2022) Planta, 256, 99.
Stander, E.A., Cuello C., Birer-Williams, C., Kulagina, N., Jansen, H., Carqueijeiro, I., Méteignier, L.V., Vergès, V., Oudin A., Papon, N., Dirks, R., Jensen, M.K., O'Connor, S.E., Dugé de Bernonville, T., Besseau, S., Courdavault, V.* (2022) . G3, jkac268.
Yamamoto, K., Grzech, D., Koudounas, K., Stander, E.A., Caputi, L., Mimura, T., Courdavault, V., O'Connor, S.E. (2021) Plant Physiol. 187, 846-857.
Bat-Erdene, U., Billingsley, J.M., Turner, W.C., Lichman, B.R., Ippoliti, F.M., Garg, N.K., O'Connor, S.E., Tang, Y.* (2021) ACS Catal. 11, 9898-9903.
Courdavault, V., O'Connor, S.E., Jensen, M.K., Papon, N. (2021) Nat Prod Rep. 38, 2145-2153.
Early and late steps of quinine biosynthesis.
Trenti, F., Yamamoto, K., Hong, B., Paetz, C., Nakamura, Y., O'Connor, S.E.* (2021) Org Lett. 23, 1793-1797.
The Mitragyna speciosa (Kratom) genome: a resource for data-mining potent pharmaceuticals that impact human health.
Brose, J., Lau, K.H., Dang, T.T.T., Hamilton, J.P., Martins, L.D.V., Hamberger, B., Hamberger, B., Jiang, J., O'Connor, S.E., Buell, C.R.* (2021) G3, 11, jkab058.
Symbionts, peptides, and (no) iron: How ants defend their fungal crop.
O'Connor, S.E. (2021) ACS Cent. Sci. 7, 225-227.
Rodríguez-López, C.E., Hong, B., Paetz, C., Nakamura, Y., Koudounas, K., Passeri, V., Baldoni, L., Alagna, F., Calderini, O., O'Connor, S.E.* (2021) New Phytol. 229, 2288-2301.
Alternative splicing directs a pseudo-strictosidine β-D-glucosidase modulating alkaloid synthesis.
Carqueijeiro, I., Koudounas, K., Dugé de Bernonville, T., Sepúlveda, L.J., Mosquera, A., Bomzan, P.D., Oudin, A., Lanoue, A., Besseau, S., Cruz, P.L., Kulagina, N., Stander, E.A., Burlaud-Gaillard, J., Blanchard, E., Clastre, M., Atehortùa, L., St-Pierre, B., Giglioli-Guivarc’h, N., Papon, N., Nagegowda, D.A., O’Connor, S.E., Courdavault, V. (2020) Plant Physiol. 185, 836-856.
Nicotiana benthamiana as a transient expression host to produce auxin analogs.
Davis, K., Gkotsi, D.S., Smith, D.R.M., Goss, R.J.M., Caputi, L., O'Connor, S.E.* (2020) Front Plant Sci. 11, 581675.
Stander, E.A., Sepúlveda, L.J., Dugé de Bernonville, T., Carqueijeiro, I., Koudounas, K., Cruz, P.L., Besseau, S., Lanoue, A., Papon, N., NGiglioli-Guivarc’h, N., Dirks, R., O’Connor, S.E., Atehortùa, L., Oudin, A., Courdavault, V. (2020) Biomolecules. 10, 1595.
Nguyen, T.D., O'Connor, S.E.* (2020) ACS Chem Biol. 15, 1780-1787.
The evolutionary origins of the cat attractant nepetalactone in catnip.
Lichman, B.R.*, Godden, G.T., Hamilton, J.P., Palmer ,L., Kamileen, M.O., Zhao, D., Vaillancourt, B., Wood, J.C., Sun, M., Kinser, T.J., Henry, L.K., Rodriguez-Lopez, C., Dudareva, N., Soltis, D.E., Soltis, P.S., Buell, C.R.*, O'Connor, S.E.* (2020) Sci Adv. 6, eaba0721.
Towards the microbial production of plant-derived anticancer drugs.
Courdavault, V., O’Connor, S.E., Oudin, A., Besseau, S., Papon, N. (2020)
Trends Cancer 6, 444-448
Neumann, M., Prahl, S., Caputi, L., Hill, L., Kular, B., Walter, A., Patallo, E.P., Milbredt, D., Aires, A., Schöpe, M., O'Connor, S., van Pée, K.H., Ludwig-Müller, J. (2020) Phytochemistry. 175, 112371.
Chlorinated auxins-How does Arabidopsis thaliana deal with them?
Walter, A., Caputi, L., O'Connor, S., van Pée, K.H., Ludwig-Müller, J. (2020) Int J Mol Sci. 21, 2567.
Virus-induced gene silencing: Hush genes to make them talk
Courdavault, C., Besseau, S., Oudin, A., Papon, N., O’Connor, S.E. (2020) Trends Plant Sci. 25, 714-715.
Identifying missing biosynthesis enzymes of plant natural products.
de Bernonville, T. D., Papon, N., Clastre, M., O’Connor, S. E., Courdavaul, V. (2020)
Trends Pharm. Sci. 41, 142-146.
Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids.
Caputi, L.#, Franke, J. #, Bussey, K., Farrow, S. C., Curcino Vieira, I. J., Stevenson, C. E. M., Lawson, D. M., O'Connor, S. E.* (2020) Nat. Chem. Biol. 16, 383-386.
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Dugé de Bernonville, T., Maury, S., Delaunay, A., Daviaud, C., Chaparro, C., Tost, J., O'Connor, S.E., Courdavault V. (2020) Int. J. Mol. Sci. 21, E6028.
Chung, K., O’Connor, S.E. (2020) In: Hung-Wen (Ben) Liu, Tadhg P. Begley (eds.) Comprehensive Natural Products III: Chemistry and Biology. vol. 2, pp. 642-
685.
Dávila-Lara, A., Rodríguez-López, C.E., O'Connor, S.E., Mithöfer, A. (2020) Int. J. Mol. Sci. 21, 4376.
Synthesis of (−)-Melodinine K: A case study of efficiency in natural product synthesis.
Walia, M., Teijaro, C.N., Gardner, A., Tran, T., Kang, J., Zhao, S., O'Connor, S.E., Courdavault, V., Andrade, R.B. (2020) . J. Nat. Prod. 83, 2425-2433.
Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs.
Carqueijeiro, I., Langley, C., Grzech, D., Koudouna,s K., Papon, N., O'Connor, S. E., Courdavault V. (2019) Curr. Opin. Biotechnol. 65, 17-24.
The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics.
Yamamoto, K., Takahashi, K., Caputi, L., Mizuno, H., Rodriguez-Lopez, C. E., Iwasaki, T., Ishizaki, K., Fukaki, H., Ohnishi, M., Yamazaki, M., Masujima, T., O'Connor, S. E., Mimura, T.* (2019) New Phytol. 224, 848-859.
Biosynthesis of an anti-addiction agent from the Iboga plant.
Farrow, S. C., Kamileen, M. O., Caputi, L., Bussey, K., Mundy, J. E. A., McAtee, R. C., Stephenson, C. R. J., O'Connor, S. E.* (2019) J. Am. Chem. Soc. 141, 12979-12983.
Biocatalytic strategies towards [4+2] cycloadditions.
Lichman, B. R., O'Connor, S. E., Kries, H. (2019) Chemistry. 25, 6864-6877.
Johnson, S. R., Bhat, W. W., Bibik, J., Turmo, A., Hamberger, B. (2019) Evolutionary Mint Genomics Consortium, Hamberger B. (2019) J. Biol. Chem. 294, 1349-1362.
Uncoupled activation and cyclisation in catmint reductive terpenoid biosynthesis.
Lichman, B. R., Kamileen, M. O., Titchiner, G. R., Saalbach, G., Stevenson, C. E. M., Lawson, D. M., O’Connor, S. E.* (2019) Nat. Chem. Biol. 15, 71-79
Franke, J., Kim, J., Hamilton, J. P., Zhao, D., Pham, G. M., Wiegert-Rininger, K., Crisovan, E., Newton, L., Vaillancourt, B., Tatsis, E. C., Buell, C. R.*, O’Connor, S. E.* (2018) ChemBioChem
Farrow, S. C., Kamileen, M. O., Meades, J., Ameyaw, B., Xiao, Y., O'Connor, S. E.* (2018) J. Biol. Chem. 293, 13821-13833.
Two tabersonine 6,7-epoxidases start synthesis of lochnericine-type alkaloids in Catharanthus roseus.
Carqueijeiro, I., Brown, S., Chung, K., Dang, T. T. T., Dugé de Bernonville, T., Lanoue, A., Dang, T. T., Teijaro, C., Paetz, C., Billet, K., Mosquera, A., Oudin, A., Besseau, S., Papon, N., Glévarec, G., Atehortùa, L., Clastre, M., Giglioli-Guivarc’h, N., St Pierre, B., Andrade, R., O'Connor, S., Courdavault, V. (2018) Plant Physiol. 177, 1473-1486.
Vacuole-Targeted Proteins: Ins and Outs of Subcellular Localization Studies.
Carqueijeiro, I., Sepúlveda, L. J., Mosquera, A., Payne, R., Corbin, C., Papon, N., de Bernonville, T. D., Besseau, S., Lanoue, A., Glévarec, G., Clastre, M., St-Pierre, B., Atehortùa, L., Giglioli-Guivarc'h, N., O'Connor, S. E., Oudin, A., Courdavault, V. (2018) Methods Mol. Biol. 1789, 33-54.
Phylogenomic mining of the mints: elucidating evolution in a chemically diverse clade.
The Mint Consortium. (2018) Mol. Plant. 11, 1084-1096.
Cyclization vs. aromatization: The substrate-guided double face of cytochrome P450 homologues provides entry into both sarpagan and β-carboline alkaloids.
Dang, T. T. T., Franke, J., Carqueijeiro, I., Langley, C., Courdavault, V., O’Connor, S. E.* (2018) Nat. Chem. Biol. 14, 760-763.
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.
Caputi, L., Franke, J., Farrow, S. C., Chung, K., Payne, R. M. E., Nguyen, T.-D.,Dang, T. T. T., Carqueijeiro, I. S. T., Koudounas, K., Dugé de Bernonville, T., Ameyaw, B., Jones, D. M., Vieira, I. J. C., Courdavault, V.*, O'Connor, S. E.* (2018) Science. 360, 1235-1239.
Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology.
Casini, A., Chang, F.-Y., Eluere, R., King, A., Young, E., Dudley, Q., Karim, A., Pratt, K., Bristol, C., Forget, A., Ghodasara, A., Warden-Rothman, R., Gan, R., Cristofaro, A., Espah Borujeni, A., Ryu, M.-H., Li, J., Kwon, Y., Wang, H., Tatsis, E., Rodriguez-Lopez, C., O'Connor, S., Medema, M., Fischbach, M., Jewett, M., Voigt, C., Gordon, D. B. (2018) A J. Am. Chem. Soc. 140, 4302-4316.
Carqueijeiro, I., Dugé de Bernonville, T., Lanoue, A., Dang, T. T., Teijaro, C., Paetz, C., Billet, K., Mosquera, A., Oudin, A., Besseau, S., Papon, N., Glévarec, G., Atehortùa, L., Clastre, M., Giglioli-Guivarc’h, N., Schneider, B., St Pierre, B., Andrade, R., O'Connor, S., Courdavault, V. (2018) Plant J. 94, 469-484
Stavrinides, A. K., Tatsis, E. C., Dang, T. T., Caputi, L., Stevenson, C. E. M., Lawson, D. M., Schneider, B., O’Connor, S. E.* (2018) ChemBioChem. 19, 940-948.
Sherden, N.S., Lichman, B., Caputi, L., Zhao, D., Kamileen, M.O.,Buell, C.R., O'Connor, S.E.* (2018) Phytochemistry 145, 48-56.
Strategies to Produce Chlorinated Indole-3-Acetic Acid and Indole-3-Acetic Acid Intermediates.
Patallo, E. P., Walter, A., Milbredt, D., Thomas, M., Neumann, M., Caputi, L., O'Connor, S., Ludwig-Müller, J., van Pée, K.-H. (2017) ChemistrySelect. 2, 11148-11153.
Tatsis, E.C.#, Carqueijeiro, M.I.S.T.#,de Bernonville, T.D., Franke, J., Dang, T.T.T., Oudin, A., Lanoue, A., Lafontaine, F., Stavrinides, A.K., Clastre, M., Courdavault, V.*, O’Connor, S.E.* (2017) Nat. Commun. 8, 316.
Identification of iridoid glucoside transporters in Catharanthus roseus.
Larsen, B., Fuller, V., Pollier, J., Van Moerkercke, A., Schweizer, F., Payne, R., Colinas, M., O’Connor, S.E., Goossens, A., Halkier, B.* (2017) Plant Cell Physiol. 58, 1507-1518.
Inverted stereocontrol of iridoid synthase in snapdragon.
Kries, H., Kellner, F., Kamileen, M.O., O’Connor, S.E.* (2017) J. Biol. Chem. 292, 14659-14667.
Dang, T.T., Franke, J., Tatsis, E., O'Connor, S.E.* (2017) Angew. Chem. Int. Ed. doi: 10.1002/anie.201705010.
Leisner, C.P., Kamileen, M.O., Conway, M.E., O'Connor, S.E., Buell, C.R. (2017) PLoS One. 12, e0179417.
Dugé de Bernonville, T., Carqueijeiro, I., Lanoue, A., Lafontaine, F., Sánchez Bel, .P, Liesecke, F., Musset, K., Oudin, A., Glévarec, G., Pichon, O., Besseau, S., Clastre, M., St-Pierre, B., Flors, V., Maury, S., Huguet, E., O'Connor, S.E., Courdavault, V. (2017) Sci. Rep. 7, 40453.
An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.
Payne, R.M.E., Xu, D., Foureau, E., Soares Teto Carqueijeiro, M. I., Oudin, A., Dugé de Bernonville, T., Novak, V., Burow, M., Olsen, C.-E., Jones, D.M., Tatsis, E.C., Pendle, A., Halkier, B.A., Geu-Flores, F., Courdavault, V., Nour-Eldin, H.H., O’Connor, S. E.* (2017) Nature Plants. 3, 16208.
New developments in engineering plant metabolic pathways.
Tatsis, E.C., O'Connor, S.E. (2016) Curr. Opin. Biotech. 42, 126-132.
Jakubczyk, D., Caputi, L., Stevenson, C.E., Lawson, D.M., O'Connor, S.E.* (2016) Chem. Commun. 52, 14306-14309.
Class II cytochrome P450 reductase governs the biosynthesis of alkaloids.
Parage, C., Foureau, E., Kellner, F., Burlat, V., Mahroug, S., Lanoue, A., Dugé de Bernonville, T., Londono, M.A., Carqueijeiro, I., Oudin, A., Besseau, S., Papon, N., Glévarec, G., Atehortùa, L., Giglioli-Guivarc'h, N., St-Pierre, B., Clastre, M., O'Connor, S.E., Courdavault, V. (2016) Plant Physiol. 172, 1563-1577.
Stavrinides, A., Tatsis, E. C., Caputi, L., Foureau, E., Stevenson, C.E.M., Lawson, D.M., Courdavault, V., O'Connor, S. E.* (2016) Nat. Commun. 12116.
Structural determinants of reductive terpene cyclization in iridoid biosynthesis.
Kries, H., Caputi, L., Stevenson, C.E., Kamileen, M.O., Sherden, N.H., Geu-Flores, F., Lawson, D.M.*, O'Connor, S.E.* (2016) Nat. Chem. Biol. 12, 6-8.
Biocatalysts from alkaloid producing plants.
Kries, H., O’Connor, S.E. (2016) Curr. Opin. Chem. Biol. 31, 22-30.
Jakubczyk, D., O'Connor, S. (2016) RSC Drug Discovery Series 50(Privileged Scaffolds in Medicinal Chemistry), 379-397.
Alagna, F., Geu-Flores, F., Kries, H., Panara, F., Baldoni, L., O'Connor, S.E., Osbourn, A. (2015) J. Biol. Chem. 29, 5542-5545.
Halogenase engineering for the generation of novel natural products.
Brown S, O'Connor S.* (2015) Chembiochem 6, 2129-2135.
Metabolic engineering of secondary metabolism.
O’Connor, S. E. (2015) Ann. Rev. Gen. 49, 71-94.
Dugé de Bernonville, T., Foureau, E., Parage, C., Lanoue, A., Clastre, M., Londono, M.A., Oudin, A., Houillé, B., Papon, N., Besseau, S., Glévarec, G., Atehortùa, L., Giglioli-Guivarc'h, N., St-Pierre, B., De Luca, V., O'Connor, S.E., Courdavault, V. (2015) BMC Genomics 16, 619.
Standards for plant synthetic biology: a common syntax for exchange of DNA parts.
Patron, N. J., Orzaez, D., Marillonnet, S., Warzecha, H., Matthewman, C., Youles, M., Raitskin, O., Leveau, A., Farré, G., Rogers, C., Smith, A., Hibberd, J., Webb, A. A., Locke, J., Schornack, S., Ajioka, J., Baulcombe, D. C., Zipfel, C., Kamoun, S., Jones, J. D., Kuhn, H., Robatzek, S., Van Esse, H. P., Sanders, D., Oldroyd, G., Martin, C., Field, R, O'Connor, S., Fox S., Wulff, B., Miller, B., Breakspear, A., Radhakrishnan, G., Delaux, P. M., Loqué,, D., Granell, A., Tissier, A., Shih, P., Brutnell, T. P., Quick, W. P., Rischer, H., Fraser, P. D., Aharoni, A., Raines, C., South, P. F., Ané, J. M., Hamberger, B. R., Langdale, J., Stougaard, J., Bouwmeester, H., Udvardi, M., Murray, J. A., Ntoukakis, V., Schäfer, P., Denby, K., Edwards, K. J., Osbourn, A., Haseloff, J. (2015) New Phytol. 208, 13-19.
Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, K., Espoz, J., Purnama, P.C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J., Goossens, A. (2015) Proc. Natl. Acad. Sci. USA 112, 8130-8135.
Kellner, F., Geu-Flores, F., Sherden, N. H., Brown, S., Courdavault, V., O'Connor, S. E.* (2015) Chem. Commun. 51, 7626-7628.
Genome biology elucidation of plant natural product biosynthesis.
Kellner, F., Kim, J. Clavijo, B. J., Hamilton, J. P., Childs, K. L., Vaillancourt, B., Cepela, J., Steuernagel, B., Clissold, L., McLay, K., Buell, C. R.*, O’Connor, S. E.* (2015) Plant J. 82, 680-692.
De novo production of the plant-derived alkaloid strictosidine in yeast.
Brown, S., Clastre, M., Courdavault, V. O’Connor, S.E.* (2015) Proc. Natl. Acad. Sci. USA 112, 3205-3210.
Jakubczyk, D., Caputi, L., Hatsch, A., Nielsen, C. A. F., Diefenbacher, M., Klein, J., Molt, A., Schröder, H., Cheng, J. Z., Naesby, M., O’Connor, S. E.* (2015) Angew. Chem. Int. Ed. Engl. 54, 5117-5121.
Stavrinides, A., Tatsis, E.C., Foureau, E., Caputi, L., Kellner, F., Courdavault, V.,* O'Connor, S.E.* (2015) Chem. Biol. 19, 336-341.
Iridoid synthase activity is common among the plant progesterone 5β-reductase family.
Munkert, J., Pollier, J., Miettinen, K., Van Moerkercke, A., Payne, R., Müller-Uri, F., Burlat, V., O'Connor, S.E., Memelink, J., Kreis, W., Goossens, A. (2015) Mol. Plant 8, 136-152.
Conversion of substrate analogs suggests a Michael cyclization in iridoid biosynthesis.
Lindner, S., Geu-Flores, F., Bräse, S., Sherden, N. H.*, O'Connor, S. E.* (2014) Chem. Biol. 21, 1452-1456.
Growing the future: synthetic biology in plants.
O'Connor, S. E, Brutnell, T. P. (2014) Curr. Opin. Plant Biol. 19, iv-v.
Nielsen, C. A. F., Folly, C., Hatsch, A., Molt, A., Schröder, H., O’Connor, S. E., Naesby, M. (2014) Microb Cell Fact. 13, 95.
Biosynthesis of the ergot alkaloids.
Jakubczyk, D., Cheng, J. Z., O'Connor, S. E. (2014) Nat. Prod. Rep. 31, 1328-1338.
Besseau, S., Kellner, F., Lanoue, A., Thamm, A. M., Salim, V., Schneider, B., Geu-Flores, F., Höfer, R., Guirimand, G., Guihur, A., Oudin, A., Glevarec, G., Foureau, E., Papon, N., Clastre, M., Giglioli-Guivarc'h, N., St-Pierre, B, Werck-Reichhart, D., Burlat, V., De Luca, V., O'Connor, S. E., Courdavault, V. (2013) Plant Physiol. 163, 1792-1803.
Diversification of monoterpene indole alkaloid analogs through cross-coupling.
Runguphan, W., O'Connor, S. E.* (2013) Org. Lett. 15, 2850-2853.
Recent progress in the metabolic engineering of alkaloids in plant systems.
Glenn, W. S., Runguphan, W., O'Connor, S. E.* (2013) Curr Opin Biotechnol. 24, 354-365.
Modern methods in plant natural products themed issue.
O'Connor SE, Gibbons S. (2013) Nat. Prod. Rep. 30, 483-484.
Góngora-Castillo, E., Childs, K. L., Fedewa, G., Hamilton, J. P., Liscombe, D. K., Magallanes-Lundback, M., Mandadi, K. K., Nims, E., Runguphan, W., Vaillancourt, B., Varbanova-Herde, M., Dellapenna, D., McKnight, T. D., O'Connor, S., Buell, C. R. (2012) PLoS One. 7, e52506.
An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis.
Geu-Flores, F., Sherden, N. H., Courdavault, V., Burlat, V., Glenn, W. S., Wu, C., Nims, E., Cui, Y., O’Connor, S. E.* (2012) Nature, 492, 138-142.
Plant gene clusters and opiates.
DellaPenna D., O'Connor S. E. (2012) Science 336, 1648-1649.
Recent progress in the metabolic engineering of alkaloids in plant systems.
Glenn, W. S., Runguphan, W., O'Connor, S. E.* (2012) Curr Opin Biotechnol. 24, 354-365.
Redesign of a dioxygenase in morphine biosynthesis.
Glenn, W. S., Runguphan, W., O’Connor, S. E.* (2012) Chem. Biol. 19, 674-678.
Biocatalytic production of tetrahydroisoquinolines.
Ruff, B. M. Brase, S., O’Connor, S. E.* (2012) Tetrahedron Lett. 53, 1071-1074.
O'Connor S. E. (2012) Meth. Enzymology 515 189-206.
O'Connor, S. E.
Edited by: Civjan, Natanya
Natural Products in Chemical Biology (2012), 209-237.
The impact of structural biology on alkaloid biosynthesis research.
Panjikar, S., Stoeckigt, J., O'Connor, S., Warzecha, H.
Natural Product Reports (2012), 29(10), 1176-1200.
Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor.
Glenn, W., Nims, N. E., O'Connor, S. E.* (2011) J. Am. Chem. Soc. 133, 19346-19349.
The evolution of function in strictosidine synthase-like proteins.
Hicks, M. A., Barber II, A. E., Giddings, L. A., O’Connor, S. E., Babbitt P. C. (2011) Proteins. 79, 3082-3098.
A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus.
Liscombe, D. K., O’Connor, S. E.* (2011) Phytochemistry. 72, 1969-1977.
Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus.
Goetz, K. A., Coyle, C. M., Cheng, J. Z., O’Connor, S. E., Panaccione, D. M. (2011) Curr. Gen. 57, 201-211.
A stereoselective hydroxylation step of alkaloid biosynthesis in Catharanthus roseus.
Giddings, L. A., Liscombe, D. K., Hamilton, J. P., Childs, K. L., DellaPenna, D., Buell, C. R., O’Connor, S. E.* (2011) J. Biol. Chem. 286, 16751-16757.
Integrating carbon-halogen bond formation into medicinal plant metabolism.
Runguphan, W., Xudong, Q., O’Connor, S. E.* (2010) Nature 468, 461-464.
Liscombe, D. K. Usera, A. R., O’Connor, S. E.* (2010) Proc. Natl. Acad. Sci. USA 107, 18793-18798.
Controlling a structural branch point in ergot alkaloid biosynthesis.
Cheng, J. Z., Coyle, C. M., Panaccione, D. M., O’Connor, S. E.* (2010) J. Am. Chem. Soc. 132, 12835-12837.
Biocatalytic asymmetric formation of tetrahydro-beta-carbolines.
Bernhardt, P., Usera, A.R., O’Connor, S.E.* (2010) Tetrahedron Lett. 51, 4400-4402.
Coyle, C. M., Cheng, J. Z., O’Connor, S. E., Panaccione, D. M. (2010) App. Environ. Microbiol. 76, 3898-3903.
A role for old yellow enzyme in ergot alkaloid biosynthesis.
Cheng, J. Z., Coyle, C. M., Panaccione, D. M., O’Connor, S. E.* (2010) J. Am. Chem. Soc. 132, 1776-1777.
“Alkaloids” in Comprehensive Natural Products II
O’Connor, S. Edited by E. L. Mander, H.-W. Lui, Elsevier: Oxford, 2010; Vol. 1, pp. 977–1007.
Bernhardt, P., O'Connor, S. E.* (2009) Tetrahedron Lett. 50, 7118-7120.
Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.
Lee, H.-Y., Yerkes, N., O’Connor, S.E.* (2009) Chem. Biol. 16, 1225-1229.
Silencing of tryptamine biosynthesis for production of unnatural alkaloids in plant culture.
Runguphan, W. Maresh, J. J., O’Connor, S. E.* (2009) Proc. Natl. Acad. Sci. USA 106, 13673-13678.
Chemo-enzymatic synthesis of heteroyohimbine alkaloid stereoisomers.
Bernhardt, P., Yerkes, N., O’Connor, S. E.* (2009) Org. Biomol. Chem. 7, 4166-4168.
Mechanistic advances in plant natural product enzymes.
Usera, A.R., O'Connor, S.E.* (2009) Curr. Opin. Chem. Biol. 13, 485-491.
Opportunities in metabolic engineering to enable scalable alkaloid production.
Leonard, E., Runguphan, W., O’Connor, S., Prather, K. J. (2009) Nat. Chem. Biol. 5, 292-300.
Opportunities for enzyme engineering in natural product biosynthesis.
Bernhardt, P., O’Connor, S. E.* (2009) Curr. Opin. Chem. Biol. 13, 35-42.
Metabolic reprogramming of periwinkle plant culture.
Runguphan, W., O’Connor, S. E.* (2009) Nat. Chem. Biol. 5, 151-153.
Synthesis of 4-, 5-, 6- and 7-azido tryptamines.
Friedrich, A., Brase, S., O’Connor, S. E.* (2009) Tetrahedron Lett. 50, 75-76.
Elucidation of natural product pathways in plants.
O’Connor, S. E. (2009) for "Plant-derived natural products; Synthesis, function and application" Springer, A. E. Osbourn, V. Lanzotti, Ed.
Bypassing stereoselectivity in the early steps of alkaloid biosynthesis.
Bernhardt, P., Yerkes, N., O'Connor, S. E.* (2009) Org. Biomol. Chem. 7, 4166-4168.
Strictosidine Synthase: Mechanism of a Pictet-Spengler catalyzing enzyme.
Maresh, J., Giddings, L. A., Friedrich, A., Loris, E. A., Panjikar, S., Stockigt, J.*, Peters, B.*, O’Connor, S. E.* (2008) J. Am. Chem. Soc. 130, 710-723.
Substrate specificity and diastereoselectivity of strictosidine glucosidase.
Yerkes, N., Wu, J., McCoy, E., Galan, M. C., Chen, S., O’Connor, S. E.* (2008) Bioorg. Med. Chem. Lett. 18, 3095-3098.
O’Connor, S. E. (2008) Encyclopedia of Chemical Biology. WileyBlackwell, T. Begley Ed.
Natural products from plant cell culture.
McCoy, E., O’Connor, S. E.* (2008) Prog Drug Res. 65, 331-70.
Chemoselective derivatization of unnatural alkaloids in periwinkle.
Galan, M. C., McCoy, E., O'Connor, S. E.* (2007) Chem. Comm. 3249-3251.
Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle.
Bernhardt, P., McCoy, E., O’Connor, S. E.* (2007) Chem. Biol. 14, 888-897.
Redesign of a central enzyme in alkaloid biosynthesis.
Chen, S., Galan, M. C., Carla Coltharp, O'Connor, S. E.* (2006) Chem. Biol. 13, 1137-1141.
Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus.
McCoy, E., O'Connor, S. E.* (2006) J. Am. Chem. Soc. 128, 14276-14277.
Chemistry and biology of terpene indole alkaloid biosynthesis.
O'Connor, S. E.*, Maresh, J. M. (2006) Nat. Prod. Rep. 23, 532-547.
Semisynthesis of secologanin derivatives.
Galan, M. C., O'Connor, S. E.* (2006) Tetrahedron Lett. 47, 1563-1565.
Substrate specificity of strictosidine synthase.
McCoy, E., Galan, M. C., O'Connor, S. E.* (2006) Bioorg. Med. Chem. Lett. 16, 2475-2478.
Terpene indole alkaloid biosynthesis.
O'Connor, S. E.*, McCoy, E. M. (2006) Rec. Adv. Phytochem. 40, 1-22.
publications prior to 2005:
Cryptic chlorination a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.
Vaillancourt, F. H., Yeh, E., Vosburg, D. A., O'Connor, S. E., Walsh, C. T. (2005) Nature 436, 1191-1194.
Hicks, L. M.; O'Connor, S. E.; Mazur, M. T., Walsh, C. T., Kelleher, N. L. (2004) Chem. Biol. 11, 327-335.
Aureolic acids: Similar antibiotics with different biosynthetic gene clusters.
O'Connor, Sarah (2004) Chem. Biol. 11, 8-10.
Couch, R., O'Connor, S. E., Seidle, H., Walsh, C. T., Parry, R. (2004) J. Bacteriol. 186, 35-42.
O'Connor, S. E., Walsh, C. T., Liu, F. (2003) Angew. Chem. Intnl. Ed. (2003), 42, 3917-3921.
Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits.
Walsh, Christopher T.; O'Connor, Sarah E.; Schneider, Tanya L. (2003) J. Ind. Microbiol. Biotechnol. 30, 448-455.
Schneider, T. L., Walsh, C. T., O'Connor, S. E. (2002) J. Am. Chem. Soc. 124, 11272-11273.
O'Connor, S. E., Chen, H., Walsh, C. T. (2002) Biochemistry. 41, 5685-5694.
Formation of β-hydroxy histidine in the biosynthesis of nikkomycin antibiotics.
Chen, H., Hubbard, B. K., O'Connor, S. E., Walsh, C. T. (2002) Chem. Biol. 9, 103-112.
Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit.
Chen, H., O'Connor, S., Cane, D. E., Walsh, C. T.
Chem. Biol. (2001), 8, 899-912.
Chen, H., Thomas, M. G., O'Connor, S. E., Hubbard, B. K., Burkart, M. D., Walsh, C. T. (2001) Biochemistry. 40, 11651-11659.
Probing the Effect of the Outer Saccharide Residues of N-Linked Glycans on Peptide Conformation.
O'Connor, S. E., Pohlmann, J., Imperiali, B., Saskiawan, I., Yamamoto, K. (2001) J. Am. Chem. Soc. 123, 6187-6188.
Effect of N-linked glycosylation on glycopeptide and glycoprotein structure.
Imperiali, Barbara; O'Connor, Sarah E. (1999) Curr. Opin. Chem. Biol. 3, 643-649.
Chemistry and biology of asparagine-linked glycosylation.
Imperiali, B., O'Connor, S. E., Hendrickson, T.,Kellenberger, C. (1999) Pure Appl. Chem. 71, 777-787.
A molecular basis for glycosylation-induced conformational switching.
O'Connor, S. E., Imperiali, B. (1998) Chem. Biol. 5, 427-437.
The conformational basis of asparagine-linked glycosylation.
Imperiali, B., O'Connor, S. E. (1998) Pure Appl. Chem. 70, 33-40.
Conformational Switching Asparagine-Linked Glycosylation.
O'Connor, S. E., Imperiali, B. (1997) J. Am. Chem. Soc. 119, 2295-2296.
Modulation of protein structure and function asparagine-linked glycosylation.
O'Connor, S. E., Imperali, B. (1996) Chem. Biol. 3, 803-812.