A few amino acid changes to a cytochrome P450 leads to enormous chemical diversity

See Omar and Benke's preprint showing how a single CYP71 can be mutated to lead to 4 monoterpene indole alkaloid scaffolds. They also show how a minor product of an enzymatic reaction actually plays a significant role in the plant's metabolic profile.

https://www.biorxiv.org/content/10.1101/2024.10.22.619577v1