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Publications before 2010


Synthesis and biochemical evaluation of des-vinyl secologanin aglycones with alternate stereochemistry.

Bernhardt, P., O'Connor, S. E.* (2009) Tetrahedron Lett. 50, 7118-7120.


Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.

Lee, H.-Y., Yerkes, N., O’Connor, S.E.* (2009) Chem. Biol. 16, 1225-1229.


Silencing of tryptamine biosynthesis for production of unnatural alkaloids in plant culture.

Runguphan, W. Maresh, J. J., O’Connor, S. E.* (2009) Proc. Natl. Acad. Sci. USA 106, 13673-13678.


Chemo-enzymatic synthesis of heteroyohimbine alkaloid stereoisomers.

Bernhardt, P., Yerkes, N., O’Connor, S. E.* (2009) Org. Biomol. Chem. 7, 4166-4168.

Mechanistic advances in plant natural product enzymes.

Usera, A.R., O'Connor, S.E.* (2009) Curr. Opin. Chem. Biol. 13, 485-491. 

Opportunities in metabolic engineering to enable scalable alkaloid production.

Leonard, E., Runguphan, W., O’Connor, S., Prather, K. J. (2009) Nat. Chem. Biol. 5, 292-300.

Opportunities for enzyme engineering in natural product biosynthesis.

Bernhardt, P., O’Connor, S. E.* (2009) Curr. Opin. Chem. Biol. 13, 35-42.

Metabolic reprogramming of periwinkle plant culture.

Runguphan, W., O’Connor, S. E.* (2009) Nat. Chem. Biol. 5, 151-153.

Synthesis of 4-, 5-, 6- and 7-azido tryptamines.

Friedrich, A., Brase, S., O’Connor, S. E.* (2009) Tetrahedron Lett. 50, 75-76.

Elucidation of natural product pathways in plants.

O’Connor, S. E. (2009) for "Plant-derived natural products; Synthesis, function and application" Springer, A. E. Osbourn, V. Lanzotti, Ed.

Bypassing stereoselectivity in the early steps of alkaloid biosynthesis.

Bernhardt, P., Yerkes, N., O'Connor, S. E.* (2009) Org. Biomol. Chem. 7, 4166-4168.

Strictosidine Synthase: Mechanism of a Pictet-Spengler catalyzing enzyme.

Maresh, J., Giddings, L. A., Friedrich, A., Loris, E. A., Panjikar, S., Stockigt, J.*, Peters, B.*, O’Connor, S. E.* (2008) J. Am. Chem. Soc. 130, 710-723.

Substrate specificity and diastereoselectivity of strictosidine glucosidase.

Yerkes, N., Wu, J., McCoy, E., Galan, M. C., Chen, S., O’Connor, S. E.* (2008) Bioorg. Med. Chem. Lett. 18, 3095-3098.

Alkaloid Biosynthesis.

O’Connor, S. E. (2008) Encyclopedia of Chemical Biology. WileyBlackwell, T. Begley Ed.

Natural products from plant cell culture.

McCoy, E., O’Connor, S. E.* (2008) Prog Drug Res. 65, 331-70.

Chemoselective derivatization of unnatural alkaloids in periwinkle.

Galan, M. C., McCoy, E., O'Connor, S. E.* (2007) Chem. Comm. 3249-3251.

Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle.

Bernhardt, P., McCoy, E., O’Connor, S. E.* (2007) Chem. Biol. 14, 888-897.

Redesign of a central enzyme in alkaloid biosynthesis.

Chen, S., Galan, M. C., Carla Coltharp, O'Connor, S. E.* (2006) Chem. Biol. 13, 1137-1141.


Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus.

McCoy, E., O'Connor, S. E.* (2006) J. Am. Chem. Soc. 128, 14276-14277.


Chemistry and biology of terpene indole alkaloid biosynthesis.

O'Connor, S. E.*, Maresh, J. M. (2006) Nat. Prod. Rep. 23, 532-547.


Semisynthesis of secologanin derivatives.

Galan, M. C., O'Connor, S. E.* (2006) Tetrahedron Lett. 47, 1563-1565.


Substrate specificity of strictosidine synthase.

McCoy, E., Galan, M. C., O'Connor, S. E.* (2006) Bioorg. Med. Chem. Lett. 16, 2475-2478.


Terpene indole alkaloid biosynthesis.

O'Connor, S. E.*, McCoy, E. M. (2006) Rec. Adv. Phytochem. 40, 1-22.

publications prior to 2005:

Cryptic chlorination  a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.

Vaillancourt, F. H., Yeh, E., Vosburg, D. A., O'Connor, S. E., Walsh, C. T. (2005) Nature 436, 1191-1194. 


Mass Spectrometric Interrogation of Thioester-Bound Intermediates in the Initial Stages of Epothilone Biosynthesis.

 Hicks, L. M.; O'Connor, S. E.; Mazur, M. T., Walsh, C. T., Kelleher, N. L. (2004) Chem. Biol. 11, 327-335. 


Aureolic acids: Similar antibiotics with different biosynthetic gene clusters.

O'Connor, Sarah (2004) Chem. Biol. 11, 8-10. 


Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine.

Couch, R., O'Connor, S. E., Seidle, H., Walsh, C. T., Parry, R. (2004) J. Bacteriol. 186, 35-42. 


Biosynthesis of epothilone intermediates with alternate starter units: Engineering polyketide-nonribosomal interfaces.

 O'Connor, S. E., Walsh, C. T., Liu, F. (2003) Angew. Chem. Intnl. Ed. (2003), 42, 3917-3921. 


Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits.

Walsh, Christopher T.; O'Connor, Sarah E.; Schneider, Tanya L. (2003) J. Ind. Microbiol. Biotechnol. 30, 448-455. 


Utilization of Alternate Substrates  the First Three Modules of the Epothilone Synthetase Assembly Line.

Schneider, T. L., Walsh, C. T., O'Connor, S. E. (2002) J. Am. Chem. Soc. 124, 11272-11273. 


Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces.

O'Connor, S. E., Chen, H., Walsh, C. T. (2002) Biochemistry. 41, 5685-5694. 


Formation of β-hydroxy histidine in the biosynthesis of nikkomycin antibiotics.

Chen, H., Hubbard, B. K., O'Connor, S. E., Walsh, C. T. (2002) Chem. Biol. 9, 103-112. 


Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit.

Chen, H., O'Connor, S., Cane, D. E., Walsh, C. T.

Chem. Biol. (2001), 8, 899-912. 


Aminoacyl-S-Enzyme Intermediates in β-Hydroxylations and α,β-Desaturations of Amino Acids in Peptide Antibiotics.

Chen, H., Thomas, M. G., O'Connor, S. E., Hubbard, B. K., Burkart, M. D., Walsh, C. T. (2001) Biochemistry. 40, 11651-11659. 


Probing the Effect of the Outer Saccharide Residues of N-Linked Glycans on Peptide Conformation.

O'Connor, S. E., Pohlmann, J., Imperiali, B., Saskiawan, I., Yamamoto, K. (2001) J. Am. Chem. Soc. 123, 6187-6188. 


Effect of N-linked glycosylation on glycopeptide and glycoprotein structure.

Imperiali, Barbara; O'Connor, Sarah E. (1999) Curr. Opin. Chem. Biol. 3, 643-649. 


Chemistry and biology of asparagine-linked glycosylation.

Imperiali, B., O'Connor, S. E., Hendrickson, T.,Kellenberger, C. (1999) Pure Appl. Chem. 71, 777-787. 


A molecular basis for glycosylation-induced conformational switching.

O'Connor, S. E., Imperiali, B. (1998) Chem. Biol. 5, 427-437. 


The conformational basis of asparagine-linked glycosylation.

Imperiali, B., O'Connor, S. E. (1998) Pure Appl. Chem. 70, 33-40. 


Conformational Switching  Asparagine-Linked Glycosylation.

O'Connor, S. E., Imperiali, B. (1997) J. Am. Chem. Soc. 119, 2295-2296. 


Modulation of protein structure and function  asparagine-linked glycosylation.

O'Connor, S. E., Imperali, B. (1996) Chem. Biol. 3, 803-812. 

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